English Version


Dr. rer. nat. Jingjing Zhang,

PI & Professor of Neurology, Guangdong Medical University, China

Tel:  +86-759-2387140

Email:  jj.zhang@gdmu.edu.cn;



    Dr. Jingjing Zhang received his doctoral degree in Cell Biology in the Humboldt University of Berlin, Germany. Later, he did postdoctoral training at the Max Delbrueck Center for Molecular Medicine (MDC), Berlin with Prof. Salim Seyfried. From 2011, he is employed as a professor of neurology in the Affiliated Hospital of Guangdong Medical University, China. His research interests are the development and functional modulations of tissue barriers including blood-brain barrier (BBB) and epithelial barriers. Using in vitro systems, zebrafish and mice models, his group focuses on (1) the developmental roles of Claudin family members on the barrier formation; (2) using synthesized peptides to selectively open tight junctions for the drug delivery; (3) the interactions between endothelial cells and pericytes and/or astrocytes during BBB formation; (4) protective and repair mechanisms of BBB under pathological and ischemic conditions.


1. Jingjing Zhang, Joerg Piontek, Hartwig Wolburg et al. (2010). Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proceedings of the National Academy of Sciences, 107(4), 1425-1430

2. Jingjing Zhang, Martin Liss, Hartwig Wolburg et al. (2012). Involvement of claudins in zebrafish brain ventricle morphogenesis. Annals of the New York Academy of Sciences. 2012 Jun; 1257(1):193-8

3. Chen Ni*, Chunhui Wang*, Jingjing Zhang*(*Co-first author) et al. (2014). Interferon-γ safeguards blood-brain barrier during experimental autoimmune encephalomyelitis. Am J Pathol. 2014 Dec; 184(12):3308-20

4. Xueqian Wang, Mei Chong, Xin Wang, Hongkui Wang,Jie Zhang, Hui Xu, Jingjing Zhang*(*Corresponding author), Dong Liu* (2014). Block the function of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardia bifida. In vitro Cellular & Developmental Biology - Animal. 2015 Mar; 51(3):211-7

5. Jingjing Zhang*(*Corresponding author), Chen Ni, Zhenguo Yang et al. (2015). Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier. Exp Dermatol. 2015 Aug; 24(8):605-10

6. Zhuangbin Liao, Zhenguo Yang, Anna Piontek, Miriam Eichner, Gerd Krause, Longxuan Li, Joerg Piontek, Jingjing Zhang*(*Corresponding author) (2016). Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial Claudin-5 and its modulation of cerebral vascular permeability. Neuroscience. 2016 Jul 7; 327:53-63 (Cover Story)

7. Wenxian Wu, Chunxia Lin, Keng Wu, Lei Jiang, Xiaojing Wang, Wen Li, Haixia Zhuang, Xingliang Zhang, Hao Chen, Shupeng Li, Yue Yang, Yue Lu, Jingjing Wang, Runzhi Zhu, Liangqing Zhang, Senfang Sui, Bin Zhao*, Jingjing Zhang* (*Corresponding author), Longxuan Li*, Du Feng* (2016). FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 2016 Jul 1;35(13):1368-84

8. Jun Wen, Xunsha Sun, Huimin Chen, Huijiao Liu, Rong Lai, Jiaoxing Li, Yufang Wang, Jingjing Zhang*(*Corresponding author), Wenli Sheng* (2016). Mutation of rnf213a by TALEN causes abnormal angiogenesis and circulation defects in zebrafish. Brain Res. 2016 Aug 1; 1644:70-78

9. Shiying Luo, Yajun Yang, Zhiguo Zhong, Jingfeng Chen, Hongxin Huang, Jingjing Zhang*(*Corresponding author), Liao Cui* (2016). Tanshinol stimulates bone formation and attenuates dexamethasone-induced inhibition of osteogenesis in larval zebrafish. Journal of Orthopaedic Translation (2016) 4, 35-45

10. Shiying Luo, Jingfeng Chen , Zhiguo Zhong, Xiaohua Lv, Yajun Yang, Jingjing Zhang*(*Corresponding author), Liao Cui* (2016). Protective effects of salvianolic acid B on osteogenesis in dexamethasone-treated zebrafish larvae. Acta Pharmacol Sin 2016 Sep; 37(10):1370-1380

11. Zhang J, Qi J, Wu S, Peng L, Shi Y, Yang J, Yin Z, Gao Y, Wang C, Gong J, Zhang H, Zhang J*(*Corresponding author) and Liu D* (2017). Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Front. Physiol. 2017; 8: 214

12. Jianan Chen, Yongting Luo, Hui Hui, Tanxi Cai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang*(*Corresponding author), Xiyun Yan*  (2017). CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci U S A. 2017 Sep 05;  114(36):E7622-E7631

13. Huang X, Lian T, Guan X, Liu B, Song Z, Zhang J*(*Corresponding author), Bao S*, Tan X*, Zhu R* (2017). Dihydromyricetin reduces TGF-β via P53  activation-dependent mechanism in hepatocellular carcinoma HepG2 cells. Protein Pept Lett, doi: 10.2174/0929866524666170223143113

14. Jianan Chen, Yongting Luo, Hongxin Huang, Shuilong Wu, Jing Feng, Jingjing Zhang*(*Corresponding author), Xiyun Yan* (2017). CD146 is essential  for PDGFRβ-induced pericyte recruitment. Protein & Cell. 2017 Sep 26. doi:10.1007/s13238-017-0484-5

15. Jingjing Zhang (2010). Investigation on developmental roles of the two zebrafish Claudin5 family members. Cuvillier Verlag. ISBN: 978-3-86955-546-11, Nov. 2010

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