广东医科大学附属医院斑马鱼平台

    平台及课题组负责人介绍

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      张晶晶,男,1984年5月生,博士,广东医科大学特聘教授,博士生导师,广东省杰出青年基金获得者,首批广东省委组织部“扬帆计划”紧缺拔尖人才、首批广东省委组织部“特支计划”百千万工程-青年拔尖人才。2005年本科毕业于南开大学生命科学院;2005年起于德国马科斯普朗克细胞生物学及遗传学所(MPI-CBG) 师从细胞生物学家Kai Simons教授攻读硕士学位,2007年获德累斯顿工业大学分子生物工程专业硕士学位;2007年起在德国马克思戴尔布吕克分子医学中心(MDC)进行博士研究,2010年获德国柏林洪堡大学自然科学博士学位;2010至2011年于德国马克思戴尔布吕克分子医学中心(MDC)进行博士后研究;2010年获国家优秀自费留学生奖;2013至2014年获德国莱布尼兹基金资助于德国莱布尼兹分子药理所(FMP)从事莱布尼兹学者研究工作。迄今在PNAS,Neuroscience,EMBO J,Am J Path等主流杂志发表多篇研究论文,担任Animal Models and Experimental Medicine杂志副主编,Frontiers in Physiology等杂志编委,中国动物学会斑马鱼分会理事;第十三届湛江市政协委员,第九届湛江市青年联合会副主席,广东省湛江市政府第四届科学技术专家咨询委员会委员。


       广东医科大学附属医院斑马鱼平台

       平台特聘教授:石德利,广东医科大学附属医院特聘教授,法国国家科学研究中心主任研究员,巴黎第六大学教授,博士生导师。长期从事发育生物学领域的研究,利用斑马鱼及爪蛙等模式动物对胚胎发育过程中和人类疾病中的重要信号传递通路、关键基因的功能及调控机理进行了跨学科的研究。其代表性研究成果在Molecular Cell, Nature Communications, EMBO Journal, Development等影响因子较高的发育生物学和分子生物学国际权威学术杂志上已发表学术论文和综述文章70多篇。


    课题组研究领域

      主要利用斑马鱼、小鼠等模式动物从事:

      1. 血脑屏障发育及功能形成研究;

      2. 血脑屏障的功能调节研究;

      3. Stroke等疾病条件下血脑屏障的保护及修复机制研究。


     承担的主要科研及人才项目情况

      1. 国家自然科学基金:“低氧条件下Claudin-5参与自噬对血脑屏障的保护机制研究”(31771628)

      2. 国家自然科学基金:“紧密连接蛋白Claudin-5在斑马鱼胚胎血管发生中的作用机制研究”(31370824)

      3. 国家自然科学基金:“产气荚膜梭菌肠毒素肽段与Claudin-5的特异性结合对血脑屏障通透性调控的影响”(81102524)

      4. 德国莱布尼茨学者基金:“Claudin-3对缺氧条件下的血脑屏障保护机制研究”(A/12/93884)

      5. 广东省杰出青年科学基金:“血脑屏障发育中脑微血管内皮细胞与周细胞的相互作用机制研究”(2017A030306024)

      6. 广东省委组织部“培养高层次人才特殊支持计划-百千万工程青年拔尖人才”项目(粤人才办〔2015〕8号)

      7. 广东省委组织部“扬帆计划”引进紧缺拔尖人才项目(粤人才办〔2014〕1号)


     代表论著

      1. Jingjing Zhang, Joerg Piontek, Hartwig Wolburg et al. (2010). Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proceedings of the National Academy of Sciences, 107(4), 1425-1430.

      2. Jingjing Zhang, Martin Liss, Hartwig Wolburg et al. (2012). Involvement of claudins in zebrafish brain ventricle morphogenesis. Annals of the New York Academy of Sciences. 2012 Jun; 1257(1):193-8.

      3. Chen Ni*, Chunhui Wang*, Jingjing Zhang*(*Co-first author) et al. (2014). Interferon-γ safeguards blood-brain barrier during experimental autoimmune encephalomyelitis. Am J Pathol. 2014 Dec; 184(12):3308-20.

      4. Xueqian Wang, Mei Chong, Xin Wang, Hongkui Wang,Jie Zhang, Hui Xu, Jingjing Zhang*(*Corresponding author), Dong Liu* (2014). Block the function of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardia bifida. In vitro Cellular & Developmental Biology - Animal. 2015 Mar; 51(3):211-7.

      5. Jingjing Zhang*(*Corresponding author), Chen Ni, Zhenguo Yang et al. (2015). Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier. Exp Dermatol. 2015 Aug; 24(8):605-10.

      6. Zhuangbin Liao, Zhenguo Yang, Anna Piontek, Miriam Eichner, Gerd Krause, Longxuan Li, Joerg Piontek, Jingjing Zhang*(*Corresponding author) (2016). Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial Claudin-5 and its modulation of cerebral vascular permeability. Neuroscience. 2016 Jul 7; 327:53-63 (Cover Story).

      7. Wenxian Wu, Chunxia Lin, Keng Wu, Lei Jiang, Xiaojing Wang, Wen Li, Haixia Zhuang, Xingliang Zhang, Hao Chen, Shupeng Li, Yue Yang, Yue Lu, Jingjing Wang, Runzhi Zhu, Liangqing Zhang, Senfang Sui, Bin Zhao*, Jingjing Zhang*(*Corresponding author), Longxuan Li*, Du Feng* (2016). FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions EMBO J. 2016 Jul 1;35(13):1368-84.

      8. Jun Wen, Xunsha Sun, Huimin Chen, Huijiao Liu, Rong Lai, Jiaoxing Li, Yufang Wang, Jingjing Zhang*(*Corresponding author), Wenli Sheng* (2016). Mutation of rnf213a by TALEN causes abnormal angiogenesis and circulation defects in zebrafish. Brain Res. 2016 Aug 1; 1644:70-78.

      9. Shiying Luo, Yajun Yang, Zhiguo Zhong, Jingfeng Chen, Hongxin Huang, Jingjing Zhang*(*Corresponding author), Liao Cui* (2016). Tanshinol stimulates bone formation and attenuates dexamethasone-induced inhibition of osteogenesis in larval zebrafish. Journal of Orthopaedic Translation (2016) 4, 35-45.

      10. Shiying Luo, Jingfeng Chen , Zhiguo Zhong, Xiaohua Lv, Yajun Yang, Jingjing Zhang*(*Corresponding author), Liao Cui* (2016). Protective effects of salvianolic acid B on osteogenesis in dexamethasone-treated zebrafish larvae. Acta Pharmacol Sin 2016 Sep; 37(10):1370-1380.

      11. Zhang J, Qi J, Wu S, Peng L, Shi Y, Yang J, Yin Z, Gao Y, Wang C, Gong J, Zhang H, Zhang J*(*Corresponding author) and Liu D* (2017). Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Front. Physiol. 2017; 8: 214.

      12. Jianan Chen, Yongting Luo, Hui Hui, Tanxi Cai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang*(*Corresponding author), Xiyun Yan*  (2017). CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci U S A. 2017 Sep 05;  114(36):E7622-E7631.

      13. Huang X, Lian T, Guan X, Liu B, Song Z, Zhang J*(*Corresponding author), Bao S*, Tan X*, Zhu R* (2017). Dihydromyricetin reduces TGF-β via P53  activation-dependent mechanism in hepatocellular carcinoma HepG2 cells. Protein Pept Lett, doi: 10.2174/0929866524666170223143113.

      14. Jianan Chen, Yongting Luo, Hongxin Huang, Shuilong Wu, Jing Feng, Jingjing Zhang*(*Corresponding author), Xiyun Yan* (2017). CD146 is essential  for PDGFRβ-induced pericyte recruitment. Protein & Cell. 2017 Sep 26. doi:10.1007/s13238-017-0484-5.

      15. Huang HX, Lin H, Lan F, Wu YF, Yang ZG, Zhang JJ*(*Corresponding author). Application of bone transgenic zebrafish in antiosteoporosis chemical screening. Anim Models Exp Med. 2018;1:53-61.

        16. Jingjing Zhang (2010). Investigation on developmental roles of the two zebrafish Claudin5 family members. Cuvillier Verlag. ISBN: 978-3-86955-546-11, Nov. 2010.(英文专著)


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